The mouse monoclonal antibody has been a dominant tool in research and diagnostic and therapeutic areas. However, a new technology for generating rabbit monoclonal antibodies offers an improved alternative for the scientific community and novel opportunities for diagnostics and therapeutics.
The advantages of this new technology are numerous: higher affinity, better specificity, and recognition of non-immunogenic antigens and epitopes in rodents. There are many companies available that provide custom antibody production services.
Mouse monoclonal antibodies are the dominant tool in research as well as in diagnostic and therapeutic fields. However, new technologies for producing rabbit monoclonal antibodies offer the scientific community a better alternative and new opportunities for diagnosis and therapy.
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The advantages of this new technology are numerous: higher affinity, better specificity, and recognition of non-immunogenic antigens and epitopes in rodents.
Although immunoassays are the most popular analytical technique in clinical and non-clinical diagnosis, there are still differences between antibody developers and IVD manufacturers.
This is partly due to the lack of high-quality antibodies in immunoassays and the increasing demand for better or newer antibodies, as well as the emergence of genomics, proteomics, and epitomizes.
The effectiveness of antibodies in terms of sensitivity, specificity, linear dynamic range, matrix effect, and standardization of immunoassays determine the main determinants of IVD medical device quality. This article discusses some of the features of the rabbit immune system that lead to better antibody production, reviews the rabbit monoclonal antibody technology, and discusses its uses and potential in the diagnostic field.